There are 3 type 2 diabetes pills from Takeda approved by FDA officials that are designed to improve blood sugar levels. These would be Oseni (alogliptin and pioglitazone), Nesina (alogliptin), and Kazano (alogliptin and metflormin hydrochloride) all of which are tablets.
So what does this all mean re 3 Type 2 Diabetes Pills from Takeda Approved by FDA?
Only alogliptin is new of the active ingredients already approved by the FDA for the management of type 2 diabetes, the others already approved is metformin hydrochloride and pioglitazone.
Ninety percent of all diabetic cases in the United States suffer from type 2 diabetes or approximately 24 million Americans, as reported In an FDA communique from January 25th, 2013.
Here what the drs say about 3 Type 2 Diabetes Pills from Takeda Approved by FDA
As stated by the FDA’s Center for Drug Evaluation and Research’s Director of Metabolism and Endocrinology Products and Research, Dr. Mary Parks, M.D..
“Controlling blood sugar levels is very important in the overall treatment and care of diabetes. Alogliptin helps stimulate the release of insulin after a meal, which leads to better blood sugar control”
Nesina is designed to slow the inactivation of incretin hormones GLP-1 (glucagon-like peptide-1) and GlP (glucose-dependent insulinotropic peptide.
Fourteen human studies, including 8500 human participants with type 2 diabetes showed that Nesina was shown to be both effective and safe:
- There were reductions in HbA1c (glycosylated hemoglobin) of 0.4% to 0.6% as compared over a 26 week period against those that used a placebo, in those patients that were given Nesina.
- The most common side-effect of those using Nesina was a runny nose, upper respiratory tract infection and headache
An extensively used anti-diabetes single tablet medication, Kazano has shown in 4 clinical trials, utilizing 2500 type 2 participants, to be both safe and effective:
- Those on the therapy for at least six months showed a reduction in HbA1c of 1.1%.
- That there is a label warning in regards to lactic acidosis.
- Sore throat, back pain, stuffy/runny nose, headache, upper respiratory and urinary tract infections, diarrhea and hypertension were the most commonly reported side effects related to the use of Kazano
The first medication in the U.S. to include both TZD (thiazoldinedione) and DPP-4i in a single tablet form, Oseni has shown in 4 clinical trials using over 1500 type 2 diabetic patients to be both effective and safe
- This drug has shown additional reductions of 0.4% to 0.9% over alogliptin alone and there were reductions in HbA1c of 0.4% to 0.6% over piolitazone
- An enhanced pharmacovigilance program is required by the FDA to check for hypersensitivity reactions, any abnormalities of the liver and for pancreatitis
- A Boxed Warning on the packaging of heart failure that has been linked to pioglitazone
- The common negative side effects reported were upper respiratory infection, runny noise, sore throat, and pain in the back.
Annually, worldwide approximately $471.6 billion is spent on diabetes, this includes both types 1 and 2. As per the International Diabetes Federation, that within the next 17 years, it is estimated that this number will increase to over $595 billion annually.
At least progress is happening re 3 Type 2 Diabetes Pills from Takeda Approved by FDA it may take a long time to beat diabetes but at least every step that is gained brings us a little closer to winning the diabetes war.